Bromal hydrate

Bromal hydrate
Names
IUPAC name
2,2,2-Tribromo-1,1-ethanediol
Other names
tribromoethylidene glycol
Identifiers
CAS Number
  • 507-42-6
3D model (JSmol)
  • Interactive image
ChemSpider
  • 61488
ECHA InfoCard 100.007.340 Edit this at Wikidata
EC Number
  • 208-073-2
PubChem CID
  • 68181
UNII
  • BQU83Q7216
CompTox Dashboard (EPA)
  • DTXSID20198751 Edit this at Wikidata
InChI
  • InChI=1S/C2H3Br3O2/c3-2(4,5)1(6)7/h1,6-7H
    Key: NJHVMXFNIZTTBV-UHFFFAOYSA-N
  • C(C(Br)(Br)Br)(O)O
Properties
Chemical formula
 C2H3Br3O2
Molar mass 298.756 g·mol−1
Appearance white crystalline solid with bromal-like smell and taste[1]
Melting point 53.5 °C (128.3 °F; 326.6 K)
Solubility in water
 Soluble
Solubility Soluble in ethanol, Diethyl ether, chloroform and Glycerin
Hazards
GHS labelling:[2]
Pictograms
 GHS07: Exclamation mark
Warning
H302, H315, H319, H335
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound

Bromal hydrate is an organobromine compound with the chemical formula C2H3Br3O2. It is the bromine analogue of chloral hydrate. Bromal hydrate forms when bromal is reacted with water. It decomposes to bromal and water upon distillation.[1] It has hypnotic and analgesic properties but acts like a stimulant at lower doses.[3] Bromal hydrate is more physiologically active than its chlorine analogue, chloral hydrate.[4] Its direct effect on the heart muscles is stronger than that of chloral hydrate.[3] Its analgesic effects were attributed to the proposed metabolism to bromoform.[5]

It was also tried as a medication for epilepsy, but was found ineffective.[1]

References

  1. ^ a b c BROMAL – BROMAL HYDRATE, Stillé, A., Maisch, J. M. (1884). The National Dispensatory: Containing the Natural History, Chemistry, Pharmacy, Actions, and Uses of Medicine. Including Those Recognized in the Pharmacopoeias of the United States, Great Britain, and Germany, with Numerous References to the French Codex. H.C. Lea.
  2. ^ "Bromal hydrate". pubchem.ncbi.nlm.nih.gov.
  3. ^ a b Bromal Hydrate (page 53), Cerna, D. (1894). Notes on the newer remedies. USA: W.B. Saunders.
  4. ^ BENNETT, J. H. (1875). Researches into the Antagonism of Medicines; being the report of the Edinburgh Committee of the British Medical Association ... Reprint from the British Medical Journal. J.&A. Churchill.
  5. ^ Bromal Hydrate, E. Steinauer (1871)
  • v
  • t
  • e