BAAT

Mammalian protein found in Homo sapiens
BAAT
Identifiers
AliasesBAAT, BACAT, BAT, bile acid-CoA:amino acid N-acyltransferase, BACD1, HCHO
External IDsOMIM: 602938 MGI: 106642 HomoloGene: 1286 GeneCards: BAAT
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for BAAT
Genomic location for BAAT
Band9q31.1Start101,354,182 bp[1]
End101,385,400 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for BAAT
Genomic location for BAAT
Band4 B1|4 26.51 cMStart49,489,422 bp[2]
End49,506,557 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • liver

  • right lobe of liver

  • gallbladder

  • islet of Langerhans

  • superior frontal gyrus

  • gastrocnemius muscle

  • Brodmann area 9

  • prefrontal cortex

  • cingulate gyrus

  • cerebellum
Top expressed in
  • left lobe of liver

  • gallbladder

  • jejunum

  • thoracic diaphragm

  • yolk sac

  • kidney

  • proximal tubule

  • colon

  • pancreas

  • spleen
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • thiolester hydrolase activity
  • very long chain acyl-CoA hydrolase activity
  • signaling receptor binding
  • transferase activity
  • medium-chain acyl-CoA hydrolase activity
  • hydrolase activity
  • N-acyltransferase activity
  • palmitoyl-CoA hydrolase activity
  • long-chain acyl-CoA hydrolase activity
  • carboxylic ester hydrolase activity
  • glycine N-choloyltransferase activity
  • protein binding
  • acyltransferase activity
  • myristoyl-CoA hydrolase activity
  • acyl-CoA hydrolase activity
Cellular component
  • cytoplasm
  • peroxisome
  • peroxisomal matrix
  • cytosol
Biological process
  • bile acid conjugation
  • liver development
  • lipid metabolism
  • animal organ regeneration
  • acyl-CoA metabolic process
  • taurine metabolic process
  • bile acid metabolic process
  • glycine metabolic process
  • bile acid biosynthetic process
  • fatty acid metabolic process
  • protein targeting to peroxisome
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

570

12012

Ensembl

ENSG00000136881
ENSG00000276559

ENSMUSG00000039653

UniProt

Q14032

Q91X34

RefSeq (mRNA)

NM_001701
NM_001127610
NM_001374715

NM_007519

RefSeq (protein)

NP_001121082
NP_001692
NP_001361644

NP_031545

Location (UCSC)Chr 9: 101.35 – 101.39 MbChr 4: 49.49 – 49.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Bile acid-CoA:amino acid N-acyltransferase is an enzyme that in humans is encoded by the BAAT gene.[5]

The protein encoded by this gene is a liver enzyme that catalyzes the transfer of the bile acid moiety from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates which serve as detergents in the gastrointestinal tract.[5]

References

  1. ^ a b c ENSG00000276559 GRCh38: Ensembl release 89: ENSG00000136881, ENSG00000276559 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039653 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: BAAT bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)".

External links

Further reading

  • Johnson MR, Barnes S, Kwakye JB, Diasio RB (1991). "Purification and characterization of bile acid-CoA:amino acid N-acyltransferase from human liver". J. Biol. Chem. 266 (16): 10227–33. doi:10.1016/S0021-9258(18)99213-6. PMID 2037576.
  • Falany CN, Johnson MR, Barnes S, Diasio RB (1994). "Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase". J. Biol. Chem. 269 (30): 19375–9. doi:10.1016/S0021-9258(17)32178-6. PMID 8034703.
  • Lench NJ, Telford EA, Andersen SE, et al. (1997). "An EST and STS-based YAC contig map of human chromosome 9q22.3". Genomics. 38 (2): 199–205. doi:10.1006/geno.1996.0616. PMID 8954802.
  • Solaas K, Ulvestad A, Söreide O, Kase BF (2000). "Subcellular organization of bile acid amidation in human liver: a key issue in regulating the biosynthesis of bile salts". J. Lipid Res. 41 (7): 1154–62. doi:10.1016/S0022-2275(20)32022-8. PMID 10884298.
  • Sfakianos MK, Wilson L, Sakalian M, et al. (2003). "Conserved residues in the putative catalytic triad of human bile acid Coenzyme A:amino acid N-acyltransferase". J. Biol. Chem. 277 (49): 47270–5. doi:10.1074/jbc.M207463200. PMID 12239217.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Carlton VE, Harris BZ, Puffenberger EG, et al. (2003). "Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT". Nat. Genet. 34 (1): 91–6. doi:10.1038/ng1147. PMID 12704386. S2CID 21900697.
  • Wang H, Tamba M, Kimata M, et al. (2003). "Expression of the activity of cystine/glutamate exchange transporter, system x(c)(-), by xCT and rBAT". Biochem. Biophys. Res. Commun. 305 (3): 611–8. doi:10.1016/S0006-291X(03)00808-8. PMID 12763038.
  • O'Byrne J, Hunt MC, Rai DK, et al. (2003). "The human bile acid-CoA:amino acid N-acyltransferase functions in the conjugation of fatty acids to glycine". J. Biol. Chem. 278 (36): 34237–44. doi:10.1074/jbc.M300987200. PMID 12810727.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Pellicoro A, van den Heuvel FA, Geuken M, et al. (2007). "Human and rat bile acid-CoA:amino acid N-acyltransferase are liver-specific peroxisomal enzymes: implications for intracellular bile salt transport". Hepatology. 45 (2): 340–8. doi:10.1002/hep.21528. PMID 17256745. S2CID 6163420.
  • Tougou K, Fukuda T, Ito T, et al. (2007). "Genetic polymorphism of bile acid CoA: amino acid N-acyltransferase in Japanese individuals". Drug Metab. Pharmacokinet. 22 (2): 125–8. doi:10.2133/dmpk.22.125. PMID 17495420.


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